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NMR titration studies in acetonitrile-d3/DMSO-d6 mixtures demonstrate that diindolylurea-based receptors can form complexes with the organophosphorus nerve agent soman in organic solution.
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Preface. This report assesses the potential non-cancer and cancer effects of chemical agent GD (CAS No. 96-64-0). This document supports the activities of the Material/Chemical Risk Assessment Working Group of the Environmental Risk Assessment Program, a cooperative endeavor of the Department of Defense, Department of Energy, and Environmental Protection Agency.
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Facts About Soman. Overview of soman, including signs & symptoms, protection, & treatment. Case Definition: Nerve Agents or Organophosphates. Includes clinical description, lab criteria for diagnosis, & case classification. Emergency Response Card: Information for First Responders. Agent-specific identification, medical symptoms, prevention.
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Slow or fast heart rate. Small, pinpoint pupils. Watery eyes. Weakness. Even a tiny drop of nerve agent on the skin can cause sweating and muscle twitching where the agent touched the skin. Exposure to a large dose of soman by any route may result in these additional adverse health effects: Convulsions.
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Introduction. Chemical warfare or organophosphate nerve agents (OPNA) are threats to both civilians and military personnel worldwide. The sarin attacks in Tokyo and Syria, VX attacks in Malaysia, and Novichok attacks in England demonstrate the real threat of OPNA to civilians (Morita et al., 1995; Suzuki et al., 1995; Okumura et al., 1996; Miyaki et al., 2005; Yanagisawa et al., 2006.
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Soman (3,3-dimethylbutan-2-yl methylphosphonofluoridate) has a highly branched alkoxyl group and is one of the most lethal nerve agents with an aging half-life of 4.62 min and 1.87 min at pH 7 when bound with TcAChE 30 and HuBChE 31 respectively. Soman has two chiral centers, namely the P and Cα atoms and the stereochemistry of the P atom is inverted once a covalent adduct is formed between 32.
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Volume 149, number 1 FEBS LETTERS November 1982 Quantification of the organophosphorus nerve agent soman by competitive inhibition enzyme immunoassay using monoclonal antibody
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The organophosphate nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) are among the most toxic chemical warfare agents known. [1, 2] Together they comprise the G-series nerve agents, thus named because German scientists first synthesized them, beginning with GA in 1936.The more highly toxic V-series agents ("V" stands for venomous)—principally, O-ethyl S-(2.
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The user should verify compliance of the cards with the relevant STATE or TERRITORY legislation before use. NIOSH, CDC 2003. Soman (military designation GD) is one of the nerve agents, which are the most toxic of the known chemical warfare agents. It has an odor like camphor or rotting fruit. Exposure to soman can cause death in minutes.
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The primary aim of this work is to provide relative response factors [25] (RRFs) as target-based standards, referred to in this study as focusing agents, for G-series agents and sulfur mustard quantification after analyzed by two different HAPSITE® ER systems.Our previous work shows system-level improvement in the data quality when switching from external and internal standards to in-situ.
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March 7, 2003 Page 1 of 5 FACT SHEET Facts About Soman What soman is • Soman is a human-made chemical warfare agent classified as a nerve agent.
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Oral. 30 mg every 8 hours beginning several hours prior to anticipated exposure. Discontinue at first sign of nerve agent poisoning; immediately treat with atropine and pralidoxime. Effects of use for >14 consecutive days not established; evaluate continuation of prophylaxis based on likelihood of exposure to soman.
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Soman is a human-made chemical warfare agent classified as a nerve agent. Nerve agents are the most toxic and rapidly acting of the known chemical warfare agents. They are similar to pesticides (insect killers) called organophosphates in terms of how they work and the kinds of harmful effects they cause. However, nerve agents are much more.
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The half-life of soman in water at pH 7, 20 °C and 30 °C has been reported as 82 and 22 hours, respectively; the half-life of soman in water at pH 7.6, 20 and 30 °C has been reported as 41 and 9.6 hours, respectively (3). At a pH >10, hydrolysis to PMPA occurs within a few minutes (4).
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Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.